Pharmacogenomics Primer

Please note we are unable to grant Continuing Pharmacy Education credit to students who attended the live Precision Medicine Conference 2017.


Intended Audience

Caitrin W. McDonough, Ph.D.
Research Assistant Professor
Department of Pharmacotherapy and Translational Research
College of Pharmacy, University of Florida

Reginald F. Frye, Pharm.D., Ph.D., FCCP
Professor and Chair
Department of Pharmacotherapy and Translational Research
College of Pharmacy, University of Florida

ACPE University Activity Number

CE Hours


Dates Available
10/03/2017 – 10/03/2020

Activity Type



This course will summarize the principles of drug metabolism pharmacogenetics and genetic medicine.


Pharmacogenetics of Drug Metabolism: Parts 1-5

  • Summarize scientific principles of pharmacogenomics, including discussion of:
    • Human genetics.
    • Relationship between genotypes and phenotypes in the context of pharmacogenomics.
    • Types of polymorphisms, including single nucleotide polymorphisms.
    • Linkage disequilibrium.
    • Haplotypes and diplotypes.
    • Star-allele nomenclature.
  • Discuss the different types of studies in the pharmacogenomics literature and their corresponding levels of evidence.
  • Explain the contribution of pharmacokinetics and genetics to interindividual variability in response.
  • Discuss relevant genetic polymorphisms of important drug metabolizing enzymes and their potential clinical implications.
  • Explain the function and tissue distribution of drug transporters.
  • Discuss variations in drug transporters and their clinical significance
  • Compare pharmacogenetics and therapeutic drug monitoring (TDM)
  • List example drugs for which pharmacogenetics-guided TDM may be the most useful

Principles of Genetic Medicine: Parts I-2

  • Review DNA.
  • Explain the Human Genome Project.
  • Discuss the Central Dogma of Molecular Biology.
  • Discuss the Types of polymorphisms.
  • Define allele, genotype, and phenotype
  • Define linkage disequilibrium, haplotype, and diplotype
  • Introduce PharmGKB

Schedule of Activities

View the recorded lectures and complete a post-test.

Requirements for Successful Course Completion

View recorded lectures, receive a 70% or higher on final exam and complete course evaluation.

Program Financial Support

This course received no outside funding support.

Acknowledgement and Disclosures

Reginald F. Frye, Pharm.D., Ph.D., FCCP, Pharm.D, CDE, FAPhA has disclosed that he has no relevant financial disclosures. No one else in a position to control content has any financial relationships to disclose.

Computer Requirements

Computer and Internet access are required to complete this course. Course content is provided via Canvas.

The minimum hardware, software, and Internet requirements for Canvas can be found here.


Refund Policy for CE Courses
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Reporting Credit

The University of Florida College of Pharmacy will report credit to CPE Monitor and CE Broker when applicable. If you would like a paper statement of credit, you may print it from your NABP e-profile.


This course  in its entirety is copyrighted by the University of Florida Continuing Pharmacy Education and may not be duplicated or reproduced for any other purpose without specific written permission.

Contact Information

For questions or more information, please contact our office.


The University of Florida College of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.